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Invitrogen™ Phospho-VAV1 (Tyr160) Polyclonal Antibody
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Catalog No. 44482
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44-482 100 μL
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Catalog No. 44-482 Supplier Invitrogen™ Supplier No. 44482
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Description

Rabbit Polyclonal Antibody

Phospho-VAV1 (Tyr160) Polyclonal Antibody for IP, Western Blot

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
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Specifications

Antigen Phospho-VAV1 (Tyr160)
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene VAV1
Gene Accession No. P15498
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Rabbit
Immunogen A chemically synthesized phosphopeptide derived from a region of human Vav1 that contains tyrosine 160.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7409
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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