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Invitrogen™ Phospho-WIPI2 (Ser413) Polyclonal Antibody
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Catalog No. PIPA5104678
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Quantity:
100 μL
Catalog No. Quantity
PIPA5104678 100 μL
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Catalog No. PIPA5104678

Supplier: Invitrogen™ PA5104678

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of WIPI2 only when phosphorylated at Ser413.

WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
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Specifications

Antigen Phospho-WIPI2 (Ser413)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene WIPI2
Gene Accession No. Q6AY57, Q80W47, Q9Y4P8
Gene Alias 1110018O08Rik; 2510001I10Rik; ATG18B; Atg21; CGI-50; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI2; WIPI-2; WIPI49-like protein 2
Gene Symbols WIPI2
Host Species Rabbit
Immunogen A synthesized peptide derived from human WIPI2(Accession Q9Y4P8), corresponding to amino acid residues around phosphorylated Ser413.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26100, 288498, 74781
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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