Invitrogen™ Phospho-WIPI2 (Ser413) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104678

Catalog No. PIPA5104678

Description

Antibody detects endogenous levels of WIPI2 only when phosphorylated at Ser413.

WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.

Specifications

• Antigen: Phospho-WIPI2 (Ser413)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WIPI2
• Gene Alias: 1110018O08Rik; 2510001I10Rik; ATG18B; Atg21; CGI-50; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI2; WIPI-2; WIPI49-like protein 2
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26100, 288498, 74781
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6AY57, Q80W47, Q9Y4P8
• Gene Symbols: WIPI2
• Immunogen: A synthesized peptide derived from human WIPI2(Accession Q9Y4P8), corresponding to amino acid residues around phosphorylated Ser413.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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