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Invitrogen™ Phospho-WRN (Ser1141) Polyclonal Antibody
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Catalog No. PIPA538932
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100 μg
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PIPA538932 100 μg
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Catalog No. PIPA538932 Supplier Invitrogen™ Supplier No. PA538932
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Description

Rabbit Polyclonal Antibody

Phospho-WRN (Ser1141) Polyclonal Antibody for Western Blot

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-WRN (Ser1141)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene WRN
Gene Accession No. Q14191
Gene Alias AI846146; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; RecQ3; RECQL2; RECQL3; RGD1564788; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog (human); Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like; WRN
Gene Symbols WRN
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141 (S-S-SP-Q-P).
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7486
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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