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Phospho-ZAP70 (Tyr493) Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A302008A
Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse
ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.Specifications
| Phospho-ZAP70 (Tyr493) | |
| Polyclonal | |
| Unconjugated | |
| ZAP70 | |
| zeta-chain (TCR) associated protein kinase 70kDa | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 7535 | |
| 4° C | |
| Liquid |
| Immunoprecipitation | |
| 1 mg/ml | |
| phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
| P43403 | |
| ZAP70 | |
| Surrounding tyrosine 493 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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