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  5. Tocris Bioscience™ PHT 427

Tocris Bioscience™ PHT 427

Catalog No. 459810
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Dual Akt and PDK1 inhibitor; antitumor

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Specifications

Purity >98%
Quantity 10 mg
Product Type PHT 427
Molecular Weight (g/mol) 409.61
Inhibitors PHT 427

For Research Use Only

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