Tocris Bioscience PHT 427
Dual Akt and PDK1 inhibitor; antitumor
Manufacturer: Tocris Bioscience 4598/50
DescriptionDual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.
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