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Tocris Bioscience™ PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Supplier: Tocris Bioscience™ 4598/50

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Catalog No. 45-985-0

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Description

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Specifications

Purity	>98%
Product Type	PHT 427
Inhibitors	PHT 427

Quantity	50 mg
Molecular Weight (g/mol)	409.61

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Tocris Bioscience™ PHT 427

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