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Echelon Biosciences Research LabsSupplier Diversity Partner AS605240 (PI3-K gamma Inhibitor 1) 1 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B03015MG

5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-Kγ (IC50 = 8 nM). It is selective for the γ-isoform (IC50: PI 3-Kα = 60 nM, PI 3-Kβ = 270 nM, PI 3-Kδ = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 μM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus.\n\n

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Solubility

\nwater: insoluble, DMSO: 2.5 mg/mL\n

Storage

\nstore dry between 2-8oC. Stock solutions should be stored frozen (-20oC).\n

References

\n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis"


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