Thermo Scientific™ NHS (N-hydroxysuccinimide)

Description

Prepare amine-reactive NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysuccinimide, CAS 6066-82-6.

Thermo Scientific™ Pierce NHS is pure N-hydroxysuccinimide, the essential compound needed to prepare amine-reactive NHS-ester crosslinkers or to enhance conjugation efficiencies when using the carbodiimide EDC.

Highlights:

• Form an acyl amino ester with carboxyl groups when used the EDC
• NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
• Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
• NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
• Reactive groups: NHS
• Reactive toward: amino groups (upon activation of carboxylates)

Specifications

• Chemical Reactivity: Amine-Carboxyl
• Cleavable: No
• Description: NHS
• Molecular Weight (g/mol): 115.09
• PEGylated: No
• Content And Storage: Upon receipt store at 4°C.
• Cell Permeability: Not determined
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Carbodiimide
• Spacer: Short (<10 Å)
• Form: Powder
• Quantity: 25 g
• Solubility: Water
• Format: Standard
• Water Soluble: Yes
• Product Type: Crosslinker

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.