Thermo Scientific™ PDPH (3-(2-pyridyldithio)propionyl hydrazide)

Description

Crosslink sulfhydryls to periodate-treated glycoprotein sugars via cleavable disulfide bonds using this short crosslinker containing pyridyldithiol and hydrazide groups.

Thermo Scientific™ Pierce PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Highlights:

• Pyridyldisulfide group provides a cleavable disulfide bond
• Oxidized carbohydrate-reactive hydrazide
• Reactive groups: pyridyldisulfide and hydrazide
• Reactive toward: sulfhydryl groups and carbohydrate
• Use with EDC for reactivity toward carboxyl groups

Specifications

• Chemical Reactivity: Carbohydrate-Sulfhydryl
• Cleavable: By Thiols
• Description: PDPH
• Molecular Weight (g/mol): 229.32
• PEGylated: No
• Spacer Arm Length: 9.2 Å
• Content And Storage: Upon receipt store desiccated at 4°C.
• Cell Permeability: Yes
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Hydrazide, Pyridyldisulfide
• Spacer: Short (<10 Å)
• Form: Powder
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard
• Water Soluble: No
• Product Type: Crosslinker

For Research Use Only. Not for use in diagnostic procedures.