Thermo Scientific™ PMPI (p-maleimidophenyl isocyanate)

Description

Short (8.7A) hydroxyl-to-sulfhydryl crosslinker; isocyanate and maleimide groups; label -OH by urethane bonds for conjugation to cysteines by thioether bonds.

Thermo Scientific™ Pierce PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds.

Highlights:

• Maleimide forms stable thioether linkages
• Isocyanate reacts with - OH groups to form a carbamate link at pH 8.5
• Excellent tool for conjugating - OH group-containing compounds such as steroids and vitamins
• Reactive groups: maleimide and isocyanate
• Reactive toward: sulfhydryl and hydroxyl groups

Specifications

• Chemical Reactivity: Carboxyl-Sulfhydryl
• Cleavable: No
• Description: PMPI
• Molecular Weight (g/mol): 307.1
• PEGylated: No
• Spacer Arm Length: 8.7 Å
• Content And Storage: Upon receipt store at 4°C protected from moisture.
• Cell Permeability: Not determined
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Maleimide, Isocyanate
• Spacer: Short (<10 Å)
• Form: Solid
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard
• Water Soluble: No
• Product Type: Crosslinker

For Research Use Only. Not for use in diagnostic procedures.