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Thermo Scientific™ SIA (succinimidyl iodoacetate)

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 3-atom (1.5A) spacer arm.

Manufacturer:  Thermo Scientific™ 22349

Catalog No. PI22349

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Thermo Scientific™ Pierce SIA is a very short (1.5 Å) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.

Suited to capturing amine and sulfhydryl groups in very close proximity


  • Reactive groups: NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups


DMSO (Dimethylsulfoxide), DMF (Dimethylformamide)
Upon receipt store at 4°C protected from moisture. Product is shipped at ambient temperature.
Haloacetyl, NHS Ester
Chemical Labeling
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