Thermo Scientific™ SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)

Description

Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.

Thermo Scientific™ Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

• Contains a hindered disulfide bond; forms stable immunotoxins
• In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-iminothiolane
• Reactive groups: NHS ester and pyridyldisulfide
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Cleavable: By Thiols
• Description: SMPT
• Molecular Weight (g/mol): 388.46
• PEGylated: No
• Spacer Arm Length: 11.2 Å
• Content And Storage: Upon receipt store desiccated at 4°C.
• Cell Permeability: Yes
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: NHS Ester, Pyridyldisulfide
• Spacer: Medium (10 to 30 Å)
• Form: Powder
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard
• Water Soluble: No
• Product Type: Crosslinker

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.