Thermo Scientific™ SPB (succinimidyl-[4-(psoralen-8-yloxy)]-butyrate)

Description

Crosslink amines to DNA with this crosslinker composed of NHS-ester and psoralen reactive groups; conjugates to DNA via light-activated intercalation next to pyrimidine bases.

Thermo Scientific™ Pierce SPB is an NHS-ester and psoralen crosslinker that effectively conjugates primary amines to DNA via light-activated intercalation next to pyrimidine bases.

Highlights:

• Melting point: 177-178°C
• Reactive groups: NHS ester and psoralen (Amax= 282nm)
• Reactive toward: amino groups pyrimidines in DNA or RNA

Specifications

• Chemical Reactivity: Amine-Nonselective
• Cleavable: No
• Description: SPB
• Molecular Weight (g/mol): 385.32
• PEGylated: No
• Spacer Arm Length: 8.6 Å
• Content And Storage: Upon receipt store desiccated at 4°C.
• Cell Permeability: Not determined
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Psoralen, NHS Ester
• Spacer: Short (<10 Å)
• Form: Solid
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard
• Water Soluble: No
• Product Type: Crosslinker

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.