Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Description

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

• Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
• Can be used as a protein thiolation reagent
• Reactive groups: NHS ester and pyridyldisulfide
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Cleavable: By Thiols
• Description: SPDP
• Molecular Weight (g/mol): 312.36
• PEGylated: No
• Spacer Arm Length: 6.8 Å
• Content And Storage: Upon receipt store at -20°C protected from moisture.
• Cell Permeability: Yes
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: NHS Ester, Pyridyldisulfide
• Spacer: Short (<10 Å)
• Form: Powder
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard, Premium-grade
• Water Soluble: No
• Product Type: Crosslinker

For Research Use Only. Not for use in diagnostic procedures.