Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

Catalog No.	Quantity
PIA39268	10 x 2 mg
PI22322	50 mg
PI22122	1 g

Catalog No. PIA39268 Supplier Thermo Scientific™ Supplier No. A39268

Description

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Thermo Scientific™ Pierce Sulfo-SMCC is a very popular, water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 Ås).

• Reactive groups: sulfo-NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Water-soluble (compare to SMCC), so crosslinking can be done in physiologic solutions
• High purity, crystalline reagent can be used to create high-purity maleimide-activated derivatives
• Cyclohexane bridge confers added stability to the maleimide group making Sulfo-SMCC the ideal crosslinking agent for maleimide activation of proteins. Maleimide groups are stable for 64 hours in 0.1 M sodium phosphate buffer, pH 7 at 4°C.

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Cleavable: No
• Description: Sulfo-SMCC
• Molecular Weight (g/mol): 436.37
• PEGylated: No
• Spacer Arm Length: 8.3 Å
• Content And Storage: Upon receipt store desiccated at -20°C.
• Cell Permeability: No
• Shipping Condition: Ambient
• Product Line: No-Weigh
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Maleimide, Sulfo-NHS Ester
• Spacer: Short (<10 Å)
• Form: Solid
• Quantity: 10 x 2 mg
• Solubility: Water
• Format: Standard, Single-use, Premium-grade
• Water Soluble: Yes
• Product Type: Crosslinker

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.