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Invitrogen™ PIEZO1 Polyclonal Antibody
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Catalog No. PIPA5106296
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PIPA5106296 100 μL
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Catalog No. PIPA5106296 Supplier Invitrogen™ Supplier No. PA5106296
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Piezo1.

Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIEZO1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Piezo1
Gene Accession No. E2JF22, Q0KL00, Q92508
Gene Alias 9630020g22; DHS; Fam38a; family with sequence similarity 38, member A; KIAA0233; LMPH3; Membrane protein induced by beta-amyloid treatment; Mib; mKIAA0233; piezo type mechanosensitive ion channel component 1; Piezo1; piezo-type mechanosensitive ion channel component 1; Protein FAM38A; protein PIEZO1
Gene Symbols Piezo1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PIEZO1(Accession Q92508), corresponding to amino acid residues I642-L692.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 234839, 361430, 9780
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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