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  7. Pifithrin-μ, Tocris Bioscience™

Pifithrin-μ, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
64984-31-2
C8H7NO2S
181.209
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
pifithrin-mu, pifithrin-, i, 2-phenylacetylenesulfonamide, phenylethynesulfonamide, phenylacetylenylsulfonamide, 2-phenylethyne-1-sulfonamide, pifithrin mu, pftmu, pifithrin-micro, pifithrin-u
327653
2-phenylethynesulfonamide
C1=CC=C(C=C1)C#CS(=O)(=O)N
This item is not returnable. View return policy
64984-31-2
C8H7NO2S
181.209
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
pifithrin-mu, pifithrin-, i, 2-phenylacetylenesulfonamide, phenylethynesulfonamide, phenylacetylenylsulfonamide, 2-phenylethyne-1-sulfonamide, pifithrin mu, pftmu, pifithrin-micro, pifithrin-u
327653
2-phenylethynesulfonamide
C1=CC=C(C=C1)C#CS(=O)(=O)N

Description

Inhibitor of p53-mitochondrial binding

Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
Quantity 10 mg
Formula Weight 181.21
Percent Purity >99%
Chemical Name or Material Pifithrin-μ

Safety and Handling

Recommended Storage : Store at +4°C