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Invitrogen™ PIGR Monoclonal Antibody (1E2B12)
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Catalog No. FERMA548572
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100 μg
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Catalog No. Quantity
FERMA548572 100 μg
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Catalog No. FERMA548572 Supplier Invitrogen™ Supplier No. MA548572
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Description

Mouse Monoclonal Antibody

PIGR Monoclonal Antibody for Western Blot, IHC (P), ELISA

Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIGR
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1E2B12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Pigr
Gene Accession No. P01833
Gene Alias hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6; phosphatidylinositol glycan, class R; Pigr; Poly Ig receptor; poly-Ig receptor; polymeric immunoglobulin receptor; Secretory component; tb6
Gene Symbols Pigr
Host Species Mouse
Immunogen Purified recombinant fragment of human PIGR (AA: extra 19-170) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5284
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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