Invitrogen™ PIGR Polyclonal Antibody

Catalog No.	Quantity
PIPA535340	400 μL

Catalog No. PIPA535340 Supplier Invitrogen™ Supplier No. PA535340

Description

Rabbit Polyclonal Antibody

PIGR Polyclonal Antibody for Flow, ICC/IF, IHC (P), Western Blot

Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.

Specifications

• Antigen: PIGR
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: Pigr
• Gene Accession No.: P01833
• Gene Alias: hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6; phosphatidylinositol glycan, class R; Pigr; Poly Ig receptor; poly-Ig receptor; polymeric immunoglobulin receptor; Secretory component; tb6
• Gene Symbols: Pigr
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 646-672 amino acids from the C-terminal region of human PIGR.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5284
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG