Invitrogen™ Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag Recombinant Protein

Catalog No.	Quantity
PV6454	20 μg

Catalog No. PV6454 Supplier Invitrogen™ Supplier No. PV6454

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is: Available in 3 convenient sizes Validated in our Adapta™ and Kinase Binding assays A full-length protein that can help advance your research when used in validated assays Related assay platforms:LanthaScreen™ Kinase Binding AssayAdapta™ Kinase Activity Assay Protein Form: Full Length, Recombinant, Active The gene accession number for PIK3CB (p110β) is NP_006210 and for PIK3R1 (p85α) is NP_852664.1.

PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.

Specifications

• Accession Number: P27986, P42338
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM sodium phosphate with 150mM Imidazole, 25% glycerol, 0.1mM PMSF, 300mM NaCl, 0.25mM DTT and no preservative; pH 7
• Gene ID (Entrez): 5291, 5295
• Molecular Weight (g/mol): 123.7-84.7 kDa
• Name: Human PIK3CB/PIK3R1 (p110 beta/p85 alpha), His Tag
• pH Range: 7
• Purification Method: Purified
• Quantity: 20 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: PIK3CB; PIK3R1
• Common Name: PIK3CB/PIK3R1
• Gene Symbol: PIK3CB, PIK3R1
• Kinase Family: PI3 Kinase
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Baculovirus
• Protein Family: Kinases & Inhibitors
• Protein Form: Full Length, Recombinant, Active
• Form: Liquid
• Research Category: Signal Transduction, Drug Development, Oncology