Invitrogen™ Human PIK3CB/PIK3R2 (p110 beta/p85 beta), His Tag Recombinant Protein

Catalog No.	Quantity
A33395	1 mg
A31084	20 μg
A32910	100 μg

Catalog No. A33395 Supplier Invitrogen™ Supplier No. A33395

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This PIK3CB/PIK3R2 (p110 beta/p85 beta) recombinant human protein (full length) was expressed in insect cells. PIK3CB/PIK3R2 (p110 beta/p85 beta) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Adapta™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for PIK3CB is NP_006210.1 and for PIK3R2 is NP_852664.1.

PIK3CB/PIK3R2 lipid kinase (p110 beta/p85 beta) or Phosphatidylinositol 3-kinase (PI3K) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit. PIK3CB plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PIK3CB sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B.

Specifications

• Accession Number: O00459, P42338
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM sodium phosphate with 0.25mM DTT, 150mM Imidazole, 25% glycerol, 0.1mM PMSF, 300mM NaCl and no preservative; pH 7
• Gene ID (Entrez): 5291, 5296
• Molecular Weight (g/mol): 123.7-83.5 kDa
• Name: Human PIK3CB/PIK3R2 (p110 beta/p85 beta), His Tag
• pH Range: 7
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: PIK3CB; PIK3R2
• Common Name: PIK3CB/PIK3R2
• Gene Symbol: PIK3CB, PIK3R2
• Kinase Family: PI3 Kinase
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Form: Full Length, Recombinant, Active
• Form: Liquid