Invitrogen™ PIM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104127

Catalog No. PIPA5104127

Description

Antibody detects endogenous levels of total PIM2.

PIM2 is a proto-oncogene which phosphorylates BAD, which partially inhibits its apopotopic function. PIM proteins (PIM-1, PIM-2 and PIM-3) are oncogene-encoded serine/threonine kinases. PIM-2 is highly homologous to Pim-1 with similar oncogenic functions. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. PIM2 expression is negatively regulated by growth factor depletion. Increased levels of PIM-2 has also been observed in certain cancers.

Specifications

• Antigen: PIM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PIM2
• Gene Alias: DXCch3; PIM2; Pim-2; pim-2 oncogene; Pim-2 proto-oncogene, serine/threonine kinase; pim-2h; proto-oncogene Pim-2 (serine threonine kinase); proviral integration site 2; serine/threonine protein kinase pim-2; serine/threonine-protein kinase pim-2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11040, 18715, 317366
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q62070, Q9P1W9
• Gene Symbols: PIM2
• Immunogen: A synthesized peptide derived from human PIM2(Accession Q9P1W9), corresponding to amino acid residues M1-G49.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov