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Invitrogen™ PINK1 Monoclonal Antibody (N4/15), APC
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Catalog No. PIMA545655
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100 μg
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PIMA545655 100 μg
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Catalog No. PIMA545655 Supplier Invitrogen™ Supplier No. MA545655
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Description

Mouse Monoclonal Antibody

82% identical to rat and 81% identical to mouse. >30% identity with DMPK. 1 μg/mL of MA5-45655 was sufficient for detection of PINK1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 50kDa. This antibody was formerly sold as clone S4-15.

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PINK1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N4/15
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene PINK1
Gene Accession No. B5DFG1, Q99MQ3, Q9BXM7
Gene Alias 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Symbols PINK1
Host Species Mouse
Immunogen Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 298575, 65018, 68943
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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