Invitrogen™ PINK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14515

Catalog No. PA14515

Description

PA1-4515 detects PINK1 in human samples. PA1-4515 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~64 kDa protein representing PINK1 in transfected HEK293T cells. PA1-4515 immunizing peptide corresponds to amino acid residues 258-274 of human PINK1.

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

Specifications

• Antigen: PINK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PINK1
• Gene Alias: 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 65018
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9BXM7
• Gene Symbols: PINK1
• Immunogen: Reacts with residues 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG