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Invitrogen™ PINK1 Polyclonal Antibody
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Catalog No. PA14515 Shop All Thermo Scientific Products
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100 μg
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PA14515 100 μg
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Catalog No. PA14515 Supplier Invitrogen™ Supplier No. PA14515
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Description

Rabbit Polyclonal Antibody

PA1-4515 detects PINK1 in human samples. PA1-4515 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~64 kDa protein representing PINK1 in transfected HEK293T cells. PA1-4515 immunizing peptide corresponds to amino acid residues 258-274 of human PINK1.

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PINK1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PINK1
Gene Accession No. Q9BXM7
Gene Alias 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Symbols PINK1
Host Species Rabbit
Immunogen Reacts with residues 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65018
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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