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Selleck Chemical LLC Pioglitazone HCl 10mg 112529-15-4 AD-4833, U-72107E
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Supplier:  Selleck Chemical LLC S204610MG

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Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 ?M, 11.8 ?M and 32.1 ?M, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPAR?) agonist with EC50 of 0.93 ?M and 0.99 ?M for human PPAR? and mouse PPAR?, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis. *For Research & Development use only.  Product is not intended for drug, household, or human consumption.

Catalog No. 50-136-1937


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