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PIP5K1A Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550346

Catalog No. PA550346


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Description

Description

The antibody detects endogenous levels of total PIP5K1A protein.

Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.
Specifications

Specifications

PIP5K1A
Polyclonal
Unconjugated
PIP5K1A
Liquid
PIP5K1A
Fusion protein corresponding to residues near the C terminal of human phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1.3 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q99755
PI51A,PIP5K1-alpha,PIP5KIalpha
Rabbit
IgG
100 μL
-20°C
Primary
8394
Documents
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