Invitrogen™ PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (9O5J1)

Catalog No.	Quantity
MA555525	100 μL

Catalog No. MA555525 Supplier Invitrogen™ Supplier No. MA555525

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen Sequence: ELRQKFERAK ISQGTKVPEE KTTNTVSKFD NNGNRDRMKL TDFNFLMVLG KGSFGKVMLS ERKGTDELYA VKILKKDVVI QDDDVECTMV EKRVLALPGK PPFLTQLHSC FQTMDRLYFV MEYVNGGDLM YHIQQVGRFK EPHAVFYAAE IAIGLFFLQS KGIIYRDLKL DNVMLDSEGH IKIADFGMCK ENIWDGVTTK T.

Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

Specifications

• Antigen: PKC alpha/beta/gamma
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 9O5J1
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
• Gene: PRKCG
• Gene Accession No.: P05129, P05696, P05771, P17252, P20444, P63318, P63319, P68403, P68404
• Gene Alias: A130082F03Rik; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit C alpha; Cs-PKA; PKA C-alpha; Pkaca; PKC; PKCA1; Pkcb; PKC-B; PKC-beta; PKCC; PKCD; PKCG; PKCgamma; PKC-gamma; PKCI; PPNAD4; PRKACA; Prkc; Prkcb; Prkcb1; Prkcb2; Prkcc; Prkcg; protein kinase A; protein kinase A alpha; protein kinase A catalytic subunit; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, gamma; protein kinase cAMP-activated catalytic subunit alpha; protein kinase, cAMP dependent, catalytic, alpha; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; RATPKCI; SCA14; sperm cAMP-dependent protein kinase catalytic subunit
• Gene Symbols: PRKCA, PRKCB, PRKCG
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-500 of human PKC alpha + beta + gamma.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18750, 18751, 18752, 24680, 24681, 25023, 5578, 5579, 5582
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG