Invitrogen™ PLA1A Polyclonal Antibody

Catalog No.	Quantity
PIPA598061	100 μg

Catalog No. PIPA598061 Supplier Invitrogen™ Supplier No. PA598061

Description

Rabbit Polyclonal Antibody

PLA1A Polyclonal Antibody for Western Blot, IHC (P), ELISA

PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.

Specifications

• Antigen: PLA1A
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene: PLA1A
• Gene Accession No.: Q53H76
• Gene Alias: AA986889; NMD; Phosphatidylserine-specific phospholipase A1; phosphatidylserine-specific phospholipase A1alpha; phospholipase A1 member A; PLA1A; PSPLA1; PS-PLA1
• Gene Symbols: PLA1A
• Host Species: Rabbit
• Immunogen: Recombinant Human Phospholipase A1 member A protein (293-398AA).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51365
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov