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Invitrogen™ Placental Alkaline Phosphatase Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA185170

Catalog No. PA185170


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Description

Description

This antibody has been found to be reactive with both placental and bone AP. Sheep anti Human Alkaline Phosphatase antibody recognizes alkaline phosphatase, it has been found to be reactive with both placental and bone alkaline phosphatase.

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Placental Alkaline Phosphatase
Polyclonal
Unconjugated
ALPP
Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; Alp1; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; Germ-cell alkaline phosphatase; glycerophosphatase; HOPS; MGC161443; MGC167935; nagao Isozyme; P PLAP; PALP; PLA2P; PLAA; placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP; PLAP1; PLAP-1; rCG23846-like; Regan isozyme; TNAP; TNSALP
Sheep
Affinity Chromatography
RUO
250
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ELISA, Immunomicroscopy, Western Blot
5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P05187
ALPP
Purified alkaline phosphatatse from human placenta.
1 mL
Primary
Human
Antibody
IgG
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