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Invitrogen™ PLK1 Monoclonal Antibody (13E8)
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Catalog No. MA1848
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100 μg
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Catalog No. Quantity
MA1848 100 μg
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Catalog No. MA1848 Supplier Invitrogen™ Supplier No. MA1848
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Description

Mouse Monoclonal Antibody

MA1-848 detects PLK1 from human, mouse, and rat samples. MA1-848 has been successfully used in Western blot, immunoprecipitation, and immunofluorescence procedures. The MA1-848 immunogen is a recombinant protein containing residues 300-400 of human PLK1.

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 13E8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Plk1
Gene Accession No. P53350, Q07832, Q62673
Gene Alias cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg
Gene Symbols Plk1
Host Species Mouse
Immunogen Recombinant protein containing residues 300-400 of human PLK1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18817, 25515, 5347
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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