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Invitrogen™ PLK4 Polyclonal Antibody
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Catalog No. PIPA529373
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100 μL
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PIPA529373 100 μL
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Catalog No. PIPA529373 Supplier Invitrogen™ Supplier No. PA529373
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: PLK4-transfected 293T. Predicted reactivity: Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene PLK4
Gene Accession No. O00444
Gene Alias 1700028H20; AI385771; MCCRP2; PLK4; PLK-4; polo like kinase 4; polo-like kinase 4; SAK; serine/threonine kinase 18; serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; Snk akin kinase; Stk18
Gene Symbols PLK4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human PLK4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10733
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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