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Invitrogen™ PMCA1 ATPase Polyclonal Antibody
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Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142821

Catalog No. PIPA5142821


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Description

Description

Additional Information: This antibody is expected to recognize both reported isoforms (NP_001001323.1; NP_001673.2). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/potassium pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PMCA1 ATPase
Polyclonal
Unconjugated
ATP2B1
2810442I22Rik; Atp2b1; ATPase plasma membrane Ca2+ transporting 1; ATPase, Ca++ transporting, plasma membrane 1; E130111D10Rik; plasma membrane Ca2+ pump (PMCA1b); plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium-transporting ATPase 1; PMCA1; Pmca1a; Pmca1b; Pmca1c; PMCA1kb
Goat
Ammonium sulfate precipitation
RUO
490
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P20020
ATP2B1
Peptide with sequence C-KQDGAIENRNKAKAQD.
100 μg
Primary
Human
Antibody
IgG
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