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Tocris Bioscience™ PMX 205

Catalog No. 51961
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51-961 1mg
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Catalog No. 51-961 Supplier Tocris Bioscience™ Supplier No. 5196/1
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Description

Potent C5a receptor peptide antagonist

PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Specifications

Purity 95%
Molecular Weight (g/mol) 839.05
Product Type PMX 205

For Research Use Only

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