Invitrogen™ PNP Polyclonal Antibody

Catalog No.	Quantity
PIPA598363	100 μL

Catalog No. PIPA598363 Supplier Invitrogen™ Supplier No. PA598363

Description

Rabbit Polyclonal Antibody

PNP Polyclonal Antibody for Western Blot, IHC (P), ELISA

The PNP gene encodes for the enzyme purine nucleoside phosphorylase, which plays a vital role in the purine salvage pathway by catalyzing the reversible cleavage of purine nucleosides. This enzyme facilitates the conversion of inosine, guanosine, and deoxyguanosine into free bases and sugars phosphorylated at the C1 position. PNP is located on chromosome 14q13 and is crucial for nucleoside catabolism, impacting energy metabolism and cellular functions across various organisms. PNP deficiency is an autosomal recessive multisystem disorder arising from mutations in the PNP gene, leading to impaired T-cell maturation and function, resulting in recurrent infections, autoimmune manifestations, and neurological abnormalities due to the toxic accumulation of deoxyguanosine triphosphate (dGTP). This deficiency particularly affects immature thymocytes and can lead to lymphoid and neuronal toxicity, underscoring the gene's importance in proper immune system function and cellular health.

Specifications

• Antigen: PNP
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PNP
• Gene Accession No.: P00491
• Gene Alias: AL024301; AU015798; endothelial dysfunction inducing protein; epididymis secretory sperm binding protein Li 156an; HEL-S-156an; inosine phosphorylase; inosine phosphorylase {ECO:0000250; Inosine-guanosine phosphorylase; Np; Np-1; Np-2; nucleoside phosphorylase; PNP; PNP {ECO:0000250; Pnp1; PRO1837; PUNP; purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250; purine-nucleoside phosphorylase; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase; UniProtKB:P00491}
• Gene Symbols: PNP
• Host Species: Rabbit
• Immunogen: Recombinant Human Purine nucleoside phosphorylase protein (1-289AA).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4860
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov