Invitrogen™ PODN Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547446

Catalog No. PIPA547446

Description

In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human Podocan is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are considered important components of the extracellular matrix. The extracellular matrix plays an integral role in the pivotal processes of development, tissue repair and metastasis by regulating cell proliferation, differentiation, adhesion and migration. Podocan, also known as PCAN, SLRR5A or PODN, is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family and the class V subfamily. Expressed in kidney, heart, liver, pancreas and vascular smooth muscle cells, Podocan exists as three alternatively spliced isoforms containing twenty LRR (leucine-rich repeats), a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. Podocan is considered a glycoprotein containing N-linked oligosaccharides that may be involved in growth regulation in cardiovascular tissues. Encoded by a gene located on human chromosome 1, Podocan interacts type I collagen (COL1).

Specifications

• Antigen: PODN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Podn
• Gene Alias: 9430070G18; Pcan; Podn; Podocan; podocan proteoglycan; PRO332; SLRR5A; UNQ293; UNQ293/PRO332
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242608
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q7TQ62
• Gene Symbols: Podn
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Podocan Val24-Arg611.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG