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Invitrogen™ Podocin Polyclonal Antibody
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Catalog No. PIPA579757
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PIPA579757 100 μg
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Catalog No. PIPA579757 Supplier Invitrogen™ Supplier No. PA579757
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat kidney tissue, human 293T whole cell. IHC: mouse kidney tissue, rat kidney tissue IHC-F: rat kidney tissue.

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Podocin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg thimerosal, 0.05mg sodium azide
Gene Nphs2
Gene Accession No. Q8K4G9, Q91X05, Q9NP85
Gene Alias AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
Gene Symbols Nphs2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human NPHS2 (368-383aa KPVEPLNPKKKDSPML).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170484, 170672, 7827
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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