Invitrogen™ POLG Polyclonal Antibody

Catalog No.	Quantity
PIPA5111441	100 μL

Catalog No. PIPA5111441 Supplier Invitrogen™ Supplier No. PA5111441

Description

Rabbit Polyclonal Antibody

Immunogen sequence: FVKGTMKDIR ENFQDLMQYC AQDVWATHEV FQQQLPLFLE RCPHPVTLAG MLEMGVSYLP VNQNWERYLA EAQGTYEELQ REMKKSLMD Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 91%.

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: POLG
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.6 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: POLG
• Gene Accession No.: P54098
• Gene Alias: AA409516; DNA polymerase gamma; DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha); DNA polymerase gamma, catalytic subunit; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; FLJ27114; MDP1; Mip1; MIRAS; Mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial DNA polymerase-gamma; mitochondrial polymerase gamma; MTDPS4A; MTDPS4B; PEO; Pol gamma; Polg; POLG1; POLGA; PolG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; polymerase, gamma; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit
• Gene Symbols: POLG
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human POLG. Recombinant protein control fragment (Product #RP-101325).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5428
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG