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Invitrogen™ POLR1A Polyclonal Antibody
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Catalog No. PIPA556766
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PIPA556766 100 μL
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Catalog No. PIPA556766 Supplier Invitrogen™ Supplier No. PA556766
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SNYEVIMKSQ HLHEVLSRAD PKKALHHFRA IKKWQSKHPN TLLRRGAFLS YSQKIQEAVK ALKLESENRN GRSPGTQEML RMWYELDEES RRKYQ Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 76%.

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLR1A
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene POLR1A
Gene Accession No. O95602
Gene Alias 194kDa; 3010014K16Rik; A190; A194; AFDCIN; DNA-directed RNA polymerase I A; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit A1; DNA-directed RNA polymerase I subunit RPA1; mRPA1; Polr1a; polymerase (RNA) I polypeptide A; polymerase (RNA) I polypeptide A, 194kDa; polymerase (RNA) I subunit A; RNA polymerase 1-4; RNA polymerase 1-4 (194 kDa subunit); RNA polymerase I (194 kDa subunit); RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A; RNA polymerase I subunit A1; Rpa1; RPA194; RPO14; RPO1-4
Gene Symbols POLR1A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human POLR1A. Recombinant protein control fragment (Product #RP-95969).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25885
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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