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Invitrogen™ POLR3A Polyclonal Antibody
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Catalog No. PIPA558170
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PIPA558170 100 μL
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Catalog No. PIPA558170 Supplier Invitrogen™ Supplier No. PA558170
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PSDDNPVRAN LRTKGKQYCG KGEDLCANDS YVTIQNSELM SGSMDKGTLG SGSKNNIFYI LLRDWGQNEA ADAMSRLARL APVYLSNRGF SI Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3A is the largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLR3A
Applications ChIP Assay, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene POLR3A
Gene Accession No. O14802
Gene Alias 9330175N20Rik; ADDH; BC053071; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; HLD7; hRPC155; POLR3A; polymerase (RNA) III (DNA directed) polypeptide A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; polymerase (RNA) III subunit A; RGD1305574; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit A; RNA polymerase III subunit C1; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155-D; RPC1; RPC155
Gene Symbols POLR3A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human POLR3A. Recombinant protein control fragment (Product #RP-97106).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11128
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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