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Invitrogen™ POLR3D Polyclonal Antibody
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Catalog No. PIPA564342
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PIPA564342 100 μL
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Catalog No. PIPA564342 Supplier Invitrogen™ Supplier No. PA564342
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LPKDVSVAEL LRELSLTKEE ELLFLQLPDT LPGQPPTQDI KPIKTEVQGE DGQVVLIKQE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLR3D
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Polr3d
Gene Accession No. P05423
Gene Alias 2810426M17Rik; 44kDa; AI326118; AW489084; BN51; BN51 (BHK21) temperature sensitivity complementing; Bn51t; DNA-directed RNA polymerase III 47 kDa polypeptide; DNA-directed RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4; HOX1C; Polr3d; polymerase (RNA) III (DNA directed) polypeptide D; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; polymerase (RNA) III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RNA polymerase III subunit C4; RNA polymerase III subunit D; RPC4; RPC53; RPC53 homolog; temperature sensitive complementation, cell cycle specific, tsBN51; TSBN51
Gene Symbols Polr3d
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human POLR3D. Recombinant protein control fragment (Product #RP-104050).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 661
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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