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  5. Tocris Bioscience™ Pomalidomide

Tocris Bioscience™ Pomalidomide
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Catalog No. 630250
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50 mg
Catalog No. Quantity
63-025-0 50 mg
63-021-0 10 mg
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Catalog No. 63-025-0

Supplier: Tocris Bioscience™ 6302/50

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Description

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Pomalidomide is a potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.

Specifications

Chemical Name or Material 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
CAS 19171-19-8
Assay Percent Range >98%
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C13H11N3O4
Formula Weight Observed MW: 273.24
Purity 98%
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