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Invitrogen™ PPAR delta Polyclonal Antibody
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Catalog No. PIPA529678
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100 μL
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PIPA529678 100 μL
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Catalog No. PIPA529678 Supplier Invitrogen™ Supplier No. PA529678
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: K562, HL-60, DDDDK-tagged PPARD delta-transfected 293T. Predicted reactivity: Mouse (95%), Rat (94%), Japanese Medaka (80%), Dog (98%), Pig (95%), Rabbit (95%), Chicken (90%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
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Specifications

Antigen PPAR delta
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Ppard
Gene Accession No. P35396, Q03181
Gene Alias FAAR; MGC3931; Nr1c2; NUC1; NUC-1; NUCI; NUCII; nuclear hormone receptor; nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferative activated receptor delta; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR[b]; PPARB; Pparb/d; PPARbeta; PPAR-beta; Ppard; PPARdelta; PPAR-delta; PPARdelta/beta
Gene Symbols Ppard
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human PPAR delta. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19015, 25682, 5467
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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