Invitrogen™ PPAR delta Polyclonal Antibody

Catalog No.	Quantity
PIPA596377	100 μL

Catalog No. PIPA596377 Supplier Invitrogen™ Supplier No. PA596377

Description

Rabbit Polyclonal Antibody

Positive Samples: BT-474, Mouse heart; Cellular Location: Nucleus Immunogen sequence: IRMKLEYEKC ERSCKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ANEGSQYNPQ VADLKAFSKH IYNAYLKNFN MTKKKARSIL TGKASHTAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYKEI SVHVFYRCQC TTVETVRELT EFAKSIPSFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD GLLVANGSGF VTREFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGGE.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Specifications

• Antigen: PPAR delta
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.26 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Ppard
• Gene Accession No.: P35396, Q03181
• Gene Alias: FAAR; MGC3931; Nr1c2; NUC1; NUC-1; NUCI; NUCII; nuclear hormone receptor; nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferative activated receptor delta; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR[b]; PPARB; Pparb/d; PPARbeta; PPAR-beta; Ppard; PPARdelta; PPAR-delta; PPARdelta/beta
• Gene Symbols: Ppard
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_8031841).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19015, 25682, 5467
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG