Invitrogen™ PPP1R9B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110207

Catalog No. PIPA5110207

Description

Immunogen sequence: VFQPPPPPPP APSGDAPAEK ERCPAGQQPP QHRVAPARPP PKPREVRKIK PVEVEESGES EAESAPGEVI QAEVTVHAAL ENGSTVATAA SPAPEEPKAQ A.

Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.

Specifications

• Antigen: PPP1R9B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ppp1r9b
• Gene Alias: Neb2; neurabin 2; neurabin II; neurabin-2; Neurabin-II; neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; PPP1R6; PPP1R9; PPP1R9B; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; SPINO; Spinophilin; SPL; Spn
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217124, 84687
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.12 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q6R891, Q96SB3
• Gene Symbols: Ppp1r9b
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PPP1R9B (NP_1159843).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG