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Invitrogen™ PPP1R9B Polyclonal Antibody
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Catalog No. PIPA5110207
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PIPA5110207 100 μL
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Catalog No. PIPA5110207 Supplier Invitrogen™ Supplier No. PA5110207
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VFQPPPPPPP APSGDAPAEK ERCPAGQQPP QHRVAPARPP PKPREVRKIK PVEVEESGES EAESAPGEVI QAEVTVHAAL ENGSTVATAA SPAPEEPKAQ A.

Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.
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Specifications

Antigen PPP1R9B
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.12 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Ppp1r9b
Gene Accession No. Q6R891, Q96SB3
Gene Alias Neb2; neurabin 2; neurabin II; neurabin-2; Neurabin-II; neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; PPP1R6; PPP1R9; PPP1R9B; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; SPINO; Spinophilin; SPL; Spn
Gene Symbols Ppp1r9b
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PPP1R9B (NP_1159843).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 217124, 84687
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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