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PPP4C Mouse anti-Human, Clone: OTI2E4, liquid, TrueMAB™
SDP

Catalog No. 501683263
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50-168-3263 100 μL
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Catalog No. 50-168-3263 Supplier OriGene Supplier No. TA810213
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Description

Mouse Monoclonal Antibody

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.

Specifications

Antigen PPP4C
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI2E4
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene PPP4C
Gene Accession No. P60510
Gene Alias PP-X, PP4, PP4C, PPH3, PPP4, PPX
Gene Symbols PPP4C
Host Species Mouse
Immunogen Full length human recombit protein of human PPP4C produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5531
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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