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Cayman Chemical PPTNhydrochlorIde 10mg
Supplier: Cayman Chemical 3685410 MG
A P2Y14 receptor antagonist; inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM; inhibits UDP-glucose-induced IL-1β and CCL2 secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat SGCs at 5 µM; trigeminal administration reduces CFA-induced mechanical hyperalgesia in rats at 5 and 10 µM
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