Invitrogen™ PR3 Monoclonal Antibody (PR3G-2), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549093

Catalog No. FERMA549093

Description

The monoclonal antibody PR3G-2 was produced by immunization of mice with a crude granule extract.

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt].

Specifications

• Antigen: PR3
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 1% BSA and 0.02% sodium azide
• Gene Accession No.: P24158
• Gene Symbols: PRTN3
• Immunogen: Monoclonal antibody PR3G-2 reacts with human proteinase 3 (PR3), a 30 kDa protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Functional Assay, Inhibition Assays, Western Blot
• Clone: PR3G-2
• Conjugate: FITC
• Gene: PRTN3
• Gene Alias: ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5657
• Content And Storage: 4°C, store in dark
• Form: Liquid