Pref-1/DLK1/FA1 Rabbit anti-Mouse, APC, Clone: 1168B, R&D Systems™
Recombinant Monoclonal Antibody
Manufacturer: R&D Systems FAB8634A100
DescriptionPref-1 (Preadipocyte factor 1), also known as Protein delta homolog 1, DLK1, FA1 and Fetal antigen 1, is a 45-60kDa transmembrane glycoprotein that is highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary. Expression of Pref-1 is elevated in liver after birth but starts to decline around postnatal day 16. Mature mouse Pref-1 is a 362 amino acid (aa) type I transmembrane N- and O-linked glycoprotein. It contains a 282 aa extracellular region (aa 24-305), a 24 aa transmembrane segment (aa 306-329), and a 56 aa cytoplasmic domain (aa 330-385). It contains 6 EGF-like domains and is involved in embryonic skeletal system development. Pref-1 inhibits preadipocyte proliferation by regulating their entry into G1/S-phase and represses preadipocyte differentiation. It is a master regulator of preadipocyte homeostasis and adipose tissue expansion. Pref-1 manipulation may, therefore, be utilized in obesity treatments. Mouse Pref-1 shares 85% and 94% aa identity with human and rat Pref-1, respectively.
|Flow Cytometry 10 uL/10^6 cells|
|delta-like 1 homolog (Drosophila), DLK, DLK1, DLK-1, FA1, FA1fetal antigen 1, pG2, pG2delta-like homolog (Drosophila), preadipocyte factor 1, Pref-1, PREF1, protein delta homolog 1, secredeltin, ZOG|
|Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.|
|Detects mouse Pref-1/DLK1/FA1 in direct ELISAs.|
|Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide|
|Mouse myeloma cell line NS0-derived recombinant mouse Pref-1/DLK1/FA1 Ala24-Gln305 Accession # Q09163|
|Protein A or G purified from cell culture supernatant|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok