Apexbio Technology LLC Rigosertib 592542-59-1 10mg

Supplier:  Apexbio Technology LLC B128810

Rigosertib (CAS 592542-59-1) is a small molecule that functions as a dual inhibitor of phosphoinositide 3-kinase (PI3K) and polo-like kinase 1 (PLK1) In cellular models Rigosertib suppresses the PI3K/AKT signaling pathway downregulates cyclin D1 induces pro-apoptotic proteins NOXA and BIM and activates the JNK pathway It promotes apoptosis in a range of human tumor cell lines including breast prostate ovarian pancreatic small cell lung colorectal cancers and melanoma with reported IC50 values typically between 50 90 nM Rigosertib is also active against drug-resistant tumor lines and influences cell cycle progression causing arrest at G1 and G2/M phases in both normal and malignant cells This profile supports its utility in cancer research particularly studies of apoptosis cell cycle regulation and kinase signaling pathways

Catalog No. 50-000-88206