Invitrogen™ PRKAR1A Monoclonal Antibody (OTI6C7)

Catalog No.	Quantity
PIMA524981	100 μL

Catalog No. PIMA524981 Supplier Invitrogen™ Supplier No. MA524981

Description

Mouse Monoclonal Antibody

PRKAR1A Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.

Specifications

• Antigen: PRKAR1A
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: OTI6C7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PRKAR1A
• Gene Accession No.: P10644, Q9DBC7
• Gene Alias: 1300018C22Rik; ACRDYS1; ADOHR; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; CAR; Carney complex type 1; CNC; CNC1; PKR1; PPNAD1; PRKAR1; Prkar1a; protein kinase A type 1a regulatory subunit; protein kinase cAMP-dependent type I regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type 1, alpha; protein kinase, cAMP dependent regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; RIalpha; RIIA; Tissue-specific extinguisher 1; Tse1; Tse-1
• Gene Symbols: PRKAR1A
• Host Species: Mouse
• Immunogen: Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector.
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19084, 5573
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1